First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.
Luyckx M, Squifflet JL, Jadoul P, Votino R, Dolmans MM, Donnez J.
Abstract
OBJECTIVE:
To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
DESIGN:
Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.
SETTING:
Academic hospital.
PATIENT(S):
Among the 52 patients, 21 wished to conceive upon treatment completion.
INTERVENTION(S):
None.
MAIN OUTCOME MEASURE(S):
Pregnancy rate and live birth rate.
RESULT(S):
Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.
CONCLUSION(S):
We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.
Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.