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First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids. 2019-02-08T13:20:28+00:00

First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.

Luyckx M, Squifflet JL, Jadoul P, Votino R, Dolmans MM, Donnez J.

Abstract

OBJECTIVE:

To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.

DESIGN:

Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.

SETTING:

Academic hospital.

PATIENT(S):

Among the 52 patients, 21 wished to conceive upon treatment completion.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Pregnancy rate and live birth rate.

RESULT(S):

Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.

CONCLUSION(S):

We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.

Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.