Mathieu Luyckx, Raffaella Votino, Jean-Luc Squifflet, Jean-François Baurain

Objective: Our aim was to review the profile of vintafolide (EC145) and its rationale for use in platinum-resistant ovarian cancer. First we investigated the folate receptors (FRs), folate’s path-way into cells, and its expression in normal and cancerous cells, before detailing the mechanism of action of vintafolide, its clinical applications, and the results of different study phases.

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Nikolaos P. Polyzos, Evangelos Sakkas, Alberto Vaiarelli, Kris Poppe, Michel Camus, and Herman Tournaye

Study question: Is there any association between thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR)?

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Objective: To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
Design: Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.

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Cannie MM, Dobrescu O, Gucciardo L, Strizek B, Ziane S, Sakkas E, Schoonjans F, Divano L, Jani JC.

Objective: To help elucidate the mechanism of action of the Arabin cervical pessary in pregnancies at high risk for preterm delivery.

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