Mathieu Luyckx, Raffaella Votino, Jean-Luc Squifflet, Jean-François Baurain
Objective: Our aim was to review the profile of vintafolide (EC145) and its rationale for use in platinum-resistant ovarian cancer. First we investigated the folate receptors (FRs), folate’s path-way into cells, and its expression in normal and cancerous cells, before detailing the mechanism of action of vintafolide, its clinical applications, and the results of different study phases.
Nikolaos P. Polyzos, Evangelos Sakkas, Alberto Vaiarelli, Kris Poppe, Michel Camus, and Herman Tournaye
Study question: Is there any association between thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR)?
Objective: To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
Design: Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.
Cannie MM, Dobrescu O, Gucciardo L, Strizek B, Ziane S, Sakkas E, Schoonjans F, Divano L, Jani JC.
Objective: To help elucidate the mechanism of action of the Arabin cervical pessary in pregnancies at high risk for preterm delivery.