Thyroid autoimmunity, hypothyroidism and ovarian reserve: a cross-sectional study of 5000 women based on age-specific AMH values

Nikolaos P. Polyzos, Evangelos Sakkas, Alberto Vaiarelli, Kris Poppe, Michel Camus, and Herman Tournaye

Study question:

Is there any association between thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR)?

Summary answer:

TAI and hypothyroidism are not associated with low ovarian reserve.

What is known already:

TAI is a common co-existent endocrinopathy in women with primary ovarian insufficiency. Several studiessupport a potential link between TAI and the reduction in ovarian reserve. However, robust evidence regarding its prevalence in women withDOR is lacking.