Publications<\/h2><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>![](\"https:\/\/www.gyn-care.gr\/wp-content\/uploads\/2020\/10\/publications.jpg\" "\\"publications\\"")
<\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>The role of transforming growth factor beta in thyroid autoimmunity: current knowledge and future perspectives<\/a><\/h1><\/div>Kardalas Efstratios 1 , Sakkas Evangelos 1 2 , Ruchala Marek 3 , Macut Djuro 4 , Mastorakos George 5<\/p>\n
Affiliations expand<\/p>\n
PMID: 34529221 DOI: 10.1007\/s11154-021-09685-7<\/p>\n
Abstract<\/p>\n
The complex mechanisms, which are related to the pathophysiology and the development of autoimmune thyroid diseases, involve transforming growth factor beta (TGF-\u03b2) and its interplay with the immune system. The aim of this review is to examine the role of TGF-\u03b2 regarding thyroid autoimmunity and explore the potent role of this molecule either as a diagnostic or prognostic marker or a therapeutic target regarding autoimmune thyroid diseases. TGF-\u03b2 is clearly a master regulator of the immune response, exerting either inhibitory or facilitatory effects on cells of the immune system.<\/span><\/p>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>Associations of Thyroid Hormones Profile During Normal Pregnancy and Postpartum With Anxiety, Depression, and Obsessive\/Compulsive Disorder Scores in Euthyroid Women<\/a><\/h1><\/div>ORIGINAL RESEARCH article – Front. Neurosci., 04 August 2021 | https:\/\/doi.org\/10.3389\/fnins.2021.663348<\/p>\n
Panagiota Konstantakou1,2, Nikos Chalarakis3, Georgios Valsamakis1, Evangelos Grigoriou Sakkas1,4, Eleni Vousoura3, Alexandros Gryparis1, Grigorios Evangelou Sakkas4, George Papadimitriou3\u2020, Ioannis Zervas3\u2020 and George Mastorakos1*\u2020
\n1Unit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece
\n2Unit of Endocrinology, Diabetes Mellitus and Metabolism, Alexandra General Hospital, Athens, Greece
\n3Department of Psychiatry, Eginition Hospital, Athens University Medical School, Athens, Greece
\n4Rea Maternity, Private Hospital, Athens, Greece<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div>Assisted Reproduction in Congenital Adrenal Hyperplasia<\/a><\/h1><\/div>Publication. Authors: Evangelos G. Sakkas, Raffaella Votino, Maria Papagianni, George Mastorakos. Anastasios Chatziaggelou<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div>IVF Myths and truths – a speech by Dr Evangelos Sakkas<\/a><\/h1><\/div>A very interesting speech took place on 25\/10\/2017 (at 19:00) at the theatre \u201cKarolos Koun\u201d. Its title was \u201cMyths and Truths in In Vitro Fertilization\u201d. It was an initiative of the Volunteer Group of the Municipality of Alimos and its Youth Center. The Obstetrician Gynecologist, Dr. Evangelos Sakkas was the main speaker, who specializes in in vitro fertilization and gynecological endocrinology.<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div>Laparoscopic Surgery in Gynecologic Oncology, 25-27\/5, Athens, Greece<\/a><\/h1><\/div>\u03a0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c4\u03bf 2\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03bb\u03b1\u03c0\u03b1\u03c1\u03bf\u03c3\u03ba\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u0393\u03c5\u03bd\u03b1\u03b9\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c3\u03c4\u03bf \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a1\u0395\u0391<\/a>. \u0397 Dr. Votino Raffaella<\/a> \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03af\u03c7\u03b5 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ad\u03b4\u03c1\u03b5\u03c5\u03c3\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03ad\u03c1\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 Session \u03bc\u03b5 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bf\u03bc\u03b9\u03bb\u03b7\u03c4\u03ad\u03c2.<\/p>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>6th Panhellenic Congress of Gynecological Endocrinology<\/a><\/h1><\/div>The role of cortisol and TGFB on thyroid function during pregnacy and postrartum period.<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div><\/div><\/div>[fusion_builder_next_page]<\/div>Publications<\/h2><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>Profile of vintafolide (EC145) and its use in the treatment of platinum-resistant ovarian cancer<\/a><\/h1><\/div>Mathieu Luyckx, Raffaella Votino, Jean-Luc Squifflet, Jean-Fran\u00e7ois Baurain<\/p>\n<\/div>
Objective:<\/strong> Our aim was to review the profile of vintafolide (EC145) and its rationale for use in platinum-resistant ovarian cancer. First we investigated the folate receptors (FRs), folate\u2019s path-way into cells, and its expression in normal and cancerous cells, before detailing the mechanism of action of vintafolide, its clinical applications, and the results of different study phases.<\/p>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>Thyroid autoimmunity, hypothyroidism and ovarian reserve: a cross-sectional study of 5000 women based on age-specific AMH values<\/a><\/h1><\/div>Nikolaos P. Polyzos, Evangelos Sakkas, Alberto Vaiarelli, Kris Poppe, Michel Camus, and Herman Tournaye<\/p>\n
\nStudy question<\/strong>: Is there any association between thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR)?<\/p>\n<\/div>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.<\/a><\/h1><\/div>Objective:<\/strong> To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
\nDesign:<\/strong> Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.<\/p>\n<\/div>
<\/span><\/div><\/div><\/div><\/div><\/div>The role of transforming growth factor beta in thyroid autoimmunity: current knowledge and future perspectives<\/a><\/h1><\/div>Kardalas Efstratios 1 , Sakkas Evangelos 1 2 , Ruchala Marek 3 , Macut Djuro 4 , Mastorakos George 5<\/p>\n
Affiliations expand<\/p>\n
PMID: 34529221 DOI: 10.1007\/s11154-021-09685-7<\/p>\n
Abstract<\/p>\n
The complex mechanisms, which are related to the pathophysiology and the development of autoimmune thyroid diseases, involve transforming growth factor beta (TGF-\u03b2) and its interplay with the immune system. The aim of this review is to examine the role of TGF-\u03b2 regarding thyroid autoimmunity and explore the potent role of this molecule either as a diagnostic or prognostic marker or a therapeutic target regarding autoimmune thyroid diseases. TGF-\u03b2 is clearly a master regulator of the immune response, exerting either inhibitory or facilitatory effects on cells of the immune system.<\/span><\/p>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>Associations of Thyroid Hormones Profile During Normal Pregnancy and Postpartum With Anxiety, Depression, and Obsessive\/Compulsive Disorder Scores in Euthyroid Women<\/a><\/h1><\/div>ORIGINAL RESEARCH article – Front. Neurosci., 04 August 2021 | https:\/\/doi.org\/10.3389\/fnins.2021.663348<\/p>\n
Panagiota Konstantakou1,2, Nikos Chalarakis3, Georgios Valsamakis1, Evangelos Grigoriou Sakkas1,4, Eleni Vousoura3, Alexandros Gryparis1, Grigorios Evangelou Sakkas4, George Papadimitriou3\u2020, Ioannis Zervas3\u2020 and George Mastorakos1*\u2020
\n1Unit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece
\n2Unit of Endocrinology, Diabetes Mellitus and Metabolism, Alexandra General Hospital, Athens, Greece
\n3Department of Psychiatry, Eginition Hospital, Athens University Medical School, Athens, Greece
\n4Rea Maternity, Private Hospital, Athens, Greece<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div>Assisted Reproduction in Congenital Adrenal Hyperplasia<\/a><\/h1><\/div>Publication. Authors: Evangelos G. Sakkas, Raffaella Votino, Maria Papagianni, George Mastorakos. Anastasios Chatziaggelou<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div>IVF Myths and truths – a speech by Dr Evangelos Sakkas<\/a><\/h1><\/div>A very interesting speech took place on 25\/10\/2017 (at 19:00) at the theatre \u201cKarolos Koun\u201d. Its title was \u201cMyths and Truths in In Vitro Fertilization\u201d. It was an initiative of the Volunteer Group of the Municipality of Alimos and its Youth Center. The Obstetrician Gynecologist, Dr. Evangelos Sakkas was the main speaker, who specializes in in vitro fertilization and gynecological endocrinology.<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div>Laparoscopic Surgery in Gynecologic Oncology, 25-27\/5, Athens, Greece<\/a><\/h1><\/div>\u03a0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c4\u03bf 2\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03bb\u03b1\u03c0\u03b1\u03c1\u03bf\u03c3\u03ba\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u0393\u03c5\u03bd\u03b1\u03b9\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c3\u03c4\u03bf \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a1\u0395\u0391<\/a>. \u0397 Dr. Votino Raffaella<\/a> \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03af\u03c7\u03b5 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ad\u03b4\u03c1\u03b5\u03c5\u03c3\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03ad\u03c1\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 Session \u03bc\u03b5 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bf\u03bc\u03b9\u03bb\u03b7\u03c4\u03ad\u03c2.<\/p>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>6th Panhellenic Congress of Gynecological Endocrinology<\/a><\/h1><\/div>The role of cortisol and TGFB on thyroid function during pregnacy and postrartum period.<\/p>\n<\/div>
Read more<\/span><\/a><\/div><\/div><\/div><\/div><\/div>[fusion_builder_next_page]<\/div>Publications<\/h2><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>Profile of vintafolide (EC145) and its use in the treatment of platinum-resistant ovarian cancer<\/a><\/h1><\/div>Mathieu Luyckx, Raffaella Votino, Jean-Luc Squifflet, Jean-Fran\u00e7ois Baurain<\/p>\n<\/div>
Objective:<\/strong> Our aim was to review the profile of vintafolide (EC145) and its rationale for use in platinum-resistant ovarian cancer. First we investigated the folate receptors (FRs), folate\u2019s path-way into cells, and its expression in normal and cancerous cells, before detailing the mechanism of action of vintafolide, its clinical applications, and the results of different study phases.<\/p>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>Thyroid autoimmunity, hypothyroidism and ovarian reserve: a cross-sectional study of 5000 women based on age-specific AMH values<\/a><\/h1><\/div>Nikolaos P. Polyzos, Evangelos Sakkas, Alberto Vaiarelli, Kris Poppe, Michel Camus, and Herman Tournaye<\/p>\n
\nStudy question<\/strong>: Is there any association between thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR)?<\/p>\n<\/div>\n<\/div>Read more<\/span><\/a><\/div><\/div><\/div>First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.<\/a><\/h1><\/div>Objective:<\/strong> To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
\nDesign:<\/strong> Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.<\/p>\n<\/div>
Kardalas Efstratios 1 , Sakkas Evangelos 1 2 , Ruchala Marek 3 , Macut Djuro 4 , Mastorakos George 5<\/p>\n
Affiliations expand<\/p>\n
PMID: 34529221 DOI: 10.1007\/s11154-021-09685-7<\/p>\n
Abstract<\/p>\n
The complex mechanisms, which are related to the pathophysiology and the development of autoimmune thyroid diseases, involve transforming growth factor beta (TGF-\u03b2) and its interplay with the immune system. The aim of this review is to examine the role of TGF-\u03b2 regarding thyroid autoimmunity and explore the potent role of this molecule either as a diagnostic or prognostic marker or a therapeutic target regarding autoimmune thyroid diseases. TGF-\u03b2 is clearly a master regulator of the immune response, exerting either inhibitory or facilitatory effects on cells of the immune system.<\/span><\/p>\n<\/div> ORIGINAL RESEARCH article – Front. Neurosci., 04 August 2021 | https:\/\/doi.org\/10.3389\/fnins.2021.663348<\/p>\n Panagiota Konstantakou1,2, Nikos Chalarakis3, Georgios Valsamakis1, Evangelos Grigoriou Sakkas1,4, Eleni Vousoura3, Alexandros Gryparis1, Grigorios Evangelou Sakkas4, George Papadimitriou3\u2020, Ioannis Zervas3\u2020 and George Mastorakos1*\u2020 Publication. Authors: Evangelos G. Sakkas, Raffaella Votino, Maria Papagianni, George Mastorakos. Anastasios Chatziaggelou<\/p>\n<\/div> A very interesting speech took place on 25\/10\/2017 (at 19:00) at the theatre \u201cKarolos Koun\u201d. Its title was \u201cMyths and Truths in In Vitro Fertilization\u201d. It was an initiative of the Volunteer Group of the Municipality of Alimos and its Youth Center. The Obstetrician Gynecologist, Dr. Evangelos Sakkas was the main speaker, who specializes in in vitro fertilization and gynecological endocrinology.<\/p>\n<\/div> \u03a0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c4\u03bf 2\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03bb\u03b1\u03c0\u03b1\u03c1\u03bf\u03c3\u03ba\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u0393\u03c5\u03bd\u03b1\u03b9\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c3\u03c4\u03bf \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a1\u0395\u0391<\/a>. \u0397 Dr. Votino Raffaella<\/a> \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03af\u03c7\u03b5 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ad\u03b4\u03c1\u03b5\u03c5\u03c3\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03ad\u03c1\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 Session \u03bc\u03b5 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bf\u03bc\u03b9\u03bb\u03b7\u03c4\u03ad\u03c2.<\/p>\n<\/div> The role of cortisol and TGFB on thyroid function during pregnacy and postrartum period.<\/p>\n<\/div> Mathieu Luyckx, Raffaella Votino, Jean-Luc Squifflet, Jean-Fran\u00e7ois Baurain<\/p>\n<\/div> Objective:<\/strong> Our aim was to review the profile of vintafolide (EC145) and its rationale for use in platinum-resistant ovarian cancer. First we investigated the folate receptors (FRs), folate\u2019s path-way into cells, and its expression in normal and cancerous cells, before detailing the mechanism of action of vintafolide, its clinical applications, and the results of different study phases.<\/p>\n<\/div> Nikolaos P. Polyzos, Evangelos Sakkas, Alberto Vaiarelli, Kris Poppe, Michel Camus, and Herman Tournaye<\/p>\n Study question<\/strong>: Is there any association between thyroid autoimmunity (TAI) and diminished ovarian reserve (DOR)?<\/p>\n<\/div>\n<\/div> Objective:<\/strong> To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.Associations of Thyroid Hormones Profile During Normal Pregnancy and Postpartum With Anxiety, Depression, and Obsessive\/Compulsive Disorder Scores in Euthyroid Women<\/a><\/h1><\/div>
\n1Unit of Endocrinology, Diabetes Mellitus and Metabolism, Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece
\n2Unit of Endocrinology, Diabetes Mellitus and Metabolism, Alexandra General Hospital, Athens, Greece
\n3Department of Psychiatry, Eginition Hospital, Athens University Medical School, Athens, Greece
\n4Rea Maternity, Private Hospital, Athens, Greece<\/p>\n<\/div>Assisted Reproduction in Congenital Adrenal Hyperplasia<\/a><\/h1><\/div>
IVF Myths and truths – a speech by Dr Evangelos Sakkas<\/a><\/h1><\/div>
Laparoscopic Surgery in Gynecologic Oncology, 25-27\/5, Athens, Greece<\/a><\/h1><\/div>
6th Panhellenic Congress of Gynecological Endocrinology<\/a><\/h1><\/div>
Publications<\/h2><\/div><\/div><\/div>
<\/span><\/div><\/div><\/div><\/div><\/div>Profile of vintafolide (EC145) and its use in the treatment of platinum-resistant ovarian cancer<\/a><\/h1><\/div>
Thyroid autoimmunity, hypothyroidism and ovarian reserve: a cross-sectional study of 5000 women based on age-specific AMH values<\/a><\/h1><\/div>
First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.<\/a><\/h1><\/div>
\nDesign:<\/strong> Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.<\/p>\n<\/div>